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Pliant Therapeutics Reports Results of P-IIa (INTEGRIS-PSC) Trial for the Treatment of Primary Sclerosing Cholangitis and Suspected Liver Fibrosis

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Pliant Therapeutics

Pliant Therapeutics Reports Results of P-IIa (INTEGRIS-PSC) Trial for the Treatment of Primary Sclerosing Cholangitis and Suspected Liver Fibrosis

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  • INTEGRIS-PSC study evaluates bexotegrast vs PBO at doses 40/80/160/320mg in patients (n=121) with PSC for 12wks. The 320mg group enrolled 27 vs 9 patients & with final data expected by mid-2024
  • The 1EP includes safety & tolerability whereas 2EP includes tolerability. The results depicted bexotegrast to be well tolerated with no DRAEs as 96% of patients in the 320mg group completed the 12wks. treatment with no drug-related severe or SAEs
  • The exploratory endpoints assessing the change in liver fibrosis markers (ELF & PRO-C3), liver biochemistry & MRI Imaging, showed a reduced ELF & PRO-C3 score vs PBO at 12wks. & an increase in relative enhancement on contrast MRI vs a decrease in PBO

Ref: Pliant Therapeutics | Image: Pliant Therapeutics

Related News:- Pliant Therapeutics Reports an Initiation of P-IIb Trial (BEACON-IPF) for Bexotegrast to Treat Idiopathic Pulmonary Fibrosis

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Shivani Chandra

Shivani was a content writer at PharmaShots. She has a keen interest in recent innovations in the life sciences industry. She was covering news related to Product approvals, clinical trial results, and updates. We can be contacted at connect@pharmashots.com.

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